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pentobarbital will lower the level or influence of estradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will reduce the level or result of irinotecan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital improves toxicity of buprenorphine, long-acting injection by ph